the effect of vitamin c supplementation on blood cholesterol level in high cholesterol-fed rats

Authors

میرهادی خیاط نوری

mir hadi khayat nouri تبریز، جاده باسمنج، دانشگاه آزاد اسلامی، دانشکده دامپزشکی، گروه علوم پایه رضا جعفری بلویردی

reza jafary bilverdi

abstract

background: hypercholesterolemia is one of the risk factors of cardiovascular diseases. it affects general health and increases cardiovascular mortality rate. diet with high cholesterol increases ldl that, inturn, decrease ldl receptors activity in liver. oxidation of vessel wall lipoproteins increases development of atherosclerosis. several evidences suggest that antioxidants consumption decreases hypercholesterolemia. this study evaluates the effect of vitamin c supplementation on blood cholesterol level in high cholesterol-fed rats. materials & methods: this work was done on 30 male wistar rats with a mean weight of 250-300 gr. they were divided into 3 groups of ten. the animals were maintained under controlled conditions (i.e. temperature: 24 ± 2˚c, dark-light cycle: 12-12 hr) and with free alless to food and water. the basal diet included wheat, corn, soybean, methionine, lysine and mixtures of mineral and vitamins. the control group received only a basic diet. two test groups received one percent cholesterol (chol) and next group received vitamin c supplementation (200 mg/kg in dry matter of diet) for one month. the one-way analysis of variance (anova) followed by the tukey multiple comparisons were used to analyze data. results: evaluation tc, ldl, hdl, vldl and tg concentrations showed that the concentrations of tc, ldl, and tg (not hdl and vldl) in chol group were significantly greater than those in control group (p<0.05). in contrast to chol group, vitamin c prevented ldl (p<0.05), tc (p<0.05), vldl and tg elevation while increased hdl amount. conclusion: vitamin c supplementation prevented changes in ldl, tc, vldl and tg of vitamin c while it increased hdl amount. this effect may be related to antioxidant and inhibitory effects of vitamin c on lipoproteins synthesis pathway.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

The effect of vitamin C supplementation on blood cholesterol level in high cholesterol-fed rats

سابقه و هدف: هیپرکلسترولمی یکی از فاکتورهای خطر بیماری‌های قلبی ـ عروقی است و افزایش کلسترول خون سلامت عمومی را تحت تاثیر قرار داده و میزان مرگ‌ و میر ناشی از بیماری‌های قلبی ـ عروقی را افزایش می‌دهد. تغذیه با رژیم پرکلسترول باعث افزایش میزان LDL و همچنین کاهش فعالیت گیرنده‌های LDL در کبد می‌شود. اکسیداسیون لیپوپروتئین موجود در دیواره عروق، باعث پیشرفت بیماری آتروسکلروز می‌شود. شواهد چندی حاکی ...

full text

Effect of individual amino acids on plasma cholesterol level in rats fed a high cholesterol diet.

The effect of individual amino acids added to a cholesterol containing casein diet on the plasma cholesterol level of rats was systematically investigated with objective of confirming the possibility that specific amino acids are responsible for the regulation of plasma cholesterol level by dietary proteins. Half the amino acids tested were effective to some degree in influencing the plasma cho...

full text

Study on the Effect of Paliurus spina-christi on Cholesterol, Triglyceride and HDL Levels in Diabetic Male Rats Fed a High Cholesterol Diet

Paliurus spina-christi Mill (Rhamnaceae) has been used in folk medicine as a hypocholesterolemic agent. In this study, the effect of total fruit extract on lowering lipid content of serum was investigated. Male rats were introduced streptozocin, subsequently fed with a high cholesterol diet and concomitantly treated with various doses of the extract. After 8 days, serum levels of cholesterol, t...

full text

Study on the Effect of Paliurus spina-christi on Cholesterol, Triglyceride and HDL Levels in Diabetic Male Rats Fed a High Cholesterol Diet

Paliurus spina-christi Mill (Rhamnaceae) has been used in folk medicine as a hypocholesterolemic agent. In this study, the effect of total fruit extract on lowering lipid content of serum was investigated. Male rats were introduced streptozocin, subsequently fed with a high cholesterol diet and concomitantly treated with various doses of the extract. After 8 days, serum levels of cholesterol, t...

full text

Effect of green tea catechins on plasma cholesterol level in cholesterol-fed rats.

Effects of tea catechins (tannins) on lipid metabolism were studied in male weanling rats fed a 25% casein diet containing 15% lard and 1% cholesterol for 28 days. Crude tea catechins prepared from green tea powder were supplemented at a 1% and 2% of the lard-cholesterol diet. The addition of 2% tea catechins slightly depressed growth but at the 1% level was without effect. Tea catechins decrea...

full text

Effect of Starvation-Refeeding Status on Cholesterol Metabolism in Rats Fed High-Cholesterol Diet

The present study investigated the effect of starvation-refeeding status on cholesterol metabolism in rats fed a high-cholesterol diet or a cholesterol-free diet. Twenty male and 20 female Donryu rats (age 5 weeks) were fed a cholesterol-free diet for 14 days. Then the male and female rats were each divided into two groups: feeding and starvation-refeeding groups. The feeding groups were fed th...

full text

My Resources

Save resource for easier access later


Journal title:
فیض

جلد ۱۰، شماره ۴، صفحات ۳۷-۴۰

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023